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DISCOVERY. THE 2014 RESEARCH REPORT OF THE UNIVERSITY OF VERMONT IMPACT. INNOVATION.

Above View of the west side of the University of Vermonts proposed Science, Technology, Engineering, and Mathematics STEM Complex. For more on the STEM Complex and its role in fostering research, see page 8. On the front and back covers A wire image of the starting point for all research and intellectual inquiry the human brain.

W e are very pleased to share with you the spirit of discovery, innovation and impact that drives the groundbreaking research taking place at the University of Vermont. UVM is a flagship research institution, and is proud to be one of the nations public landgrant universities. For more than two centuries, the University of Vermont has engaged in research leading to scientific advances, technological innovation, economic development and enhanced quality of life. The scope of research at the Univ

U N I V E R S I T Y O F V E R M O N T RESEARCH HIGHLIGHTS, FACTS FIGURES Public research universities have a fundamental responsibility to create knowledge and seek its application for the public good. At the University of Vermont, this tenet is central to our research enterprise. In service to the state, the nation, and the world, UVM discovery takes place in many settings in laboratories and clinics, agricultural farmlands and research forests, in waterways across the state and in field st

With over 40 years of research data in the lab notebooks behind him, Kenneth Mann, Ph.D., is now leading breakthrough research on coagulation and trauma. 24 Million Grant Funds Study of TraumaInduced Bleeding Syndrome W ith more than four decades of expertise in the field of blood coagulation, Kenneth Mann, Ph.D., professor emeritus of biochemistry, is perfectly matched to his role as lead investigator of a fiveyear, 23.8 million multicenter, multidisciplinary National Institutes of Health st

A Partnership Focused on Building a Smarter Grid he IGERT program for Integrative Graduate Education and Training is the National Science Foundations flagship interdisciplinary training program for preparing U.S. Ph.D. scientists and engineers to address complex, realworld problems. And that means that smart grid experts like UVMs Paul Hines, Ph.D., and his colleagues are working across traditional disciplines. The University of Vermont Smart Grid IGERT program a 3 million, fiveyear partnersh

The Next Generation of Researchers Present at UVMs Student Research Day he 2014 Annual Student Research Conference featured threehundred and thirtysix students 198 undergraduates and 138 graduate students showing posters and making oral presentations at the T UVM medical students were among the 336 graduate and undergraduate presenters at the 2014 Student Research Conference. conference. Seventyone academic programs were represented from all 10 of UVMs colleges and schools. Student projects

THE MHISSION SYSTEM EFFECTIVELY LINKS POPULATIONS TO A WIDE ARRAY OF SERVICES ... PROVIDING THE CONNECTION WITH HEALTH CARE AND HUMAN SERVICE DELIVERY IS REALLY THE ESSENCE OF WHAT IT DOES. Thomas Simpatico, M.D., Professor of Psychiatry Professor of Psychiatry Dr. Thomas Simpatico, above left, with Chittenden County States Attorney T.J. Donovan, at the Costello Courthouse building in Burlington. On a MHISSION A Public Health Approach to Justice ndividuals suffering from substance abuse and me

The Patent Pathway Ideas Born at the University of Vermont Become Real Products Companies They begin as ideas in the minds of UVM researchers. After rigorous experimentation and testing, ideas that hold promise as patentable intellectual property and products are guided along the road to official recognition and protection by the Office of Technology Commercialization OTC to become viable contributors to our economy. To learn more about the OTC, see page 45. IMPACT 438,725,000 direct indirect

U N I V E R S I T Y O F V E R M O N T RESEARCH FACILITIES The University is its people, first and foremost. But those talented faculty, dedicated staff, and inquisitive students need superior facilities to realize their full potential. This is particularly true in the area of research and instruction in the sciences, where technology, equipment, and methods rapidly and continuously evolve. Research facilities at the University of Vermont serve a wide range of fields, from advanced computing

KALKIN HALL NEW STEM COMPLEX BUILDING VOTEY HALL NEW STEM COMPLEX BUILDING LAFAYETTE HALL WILLIAMS HALL OLD MILL DISCOVER MORE Learn how you can support the STEM Complex project at UVM.EDUDISCOVERY CAMPUS HIGHLIGHTS The work of discovery goes on at UVM in many settings laboratories and clinics, waterways, farmlands and forests, on campus, throughout the state and across the region. MRI Center for Biomedical Imaging Melosira Research Vessel CAMPUS HIGHLIGHTS This researchonly facility wa

Big Data and the Vermont Advanced Computing Core upporting innovative computational research and education at the University of Vermont, the Vermont Advanced Computing Core VACC provides a valuable supercomputing resource and accessibility to the UVM research enterprise, attracting worldclass faculty and strategic partnerships to both UVM and Vermont. Required for the wealth of emerging big data studies, the VACC supports diverse, multidisciplinary, and highimpact work in social media, global cl

The Vermont State Health Laboratory is seen in the rendering above, and during actual construction in April 2014, below. Vermont State Health Laboratory and UVM Research Facility Create State Scientific Campus in Colchester After more than a decade of discussion and planning, a groundbreaking ceremony was held in April 2013 for a new Vermont State Health Laboratory colocated with the University of Vermont Colchester Research Facility. Expected to be completed in fall 2014, the 47,844squarefoot

A R E A O F F O C U S E D E X C E L L E N C E BIOMEDICAL SCIENCES The largest and most expansive research focus at UVM is in the biomedical sciences, which accounts for well over twothirds of the external funding that comes to the University. Ranging from the study of cancer at the molecular level, to bioengineering new lungs, to saving patients in their critical first hours after a stroke, physicians and biomedical scientists at UVM are engaged in creating new knowledge about disease and we

Customized Treatment for the Most Common Heart Rhythm Disorder PETER SPECTOR, M.D., PROFESSOR OF MEDICINE A s a cardiologist, Peter Spector, M.D., has seen his share of patients suffering from the nations most common heart rhythm disorder, atrial fibrillation AF. AF is characterized by extremely irregular and fluctuating heartbeat and is responsible for up to a 24 percent increase in a patients risk of stroke, and as much as a twofold increase in the risk of death. But Spector has often felt p

Daniel Weiss, M.D., Ph.D., standing, and Darcy Wagner, Ph.D., work to develop replacement lung tissue for patients with COPD and other illnesses. Setting a New Bar in Lung Regeneration Research DANIEL WEISS, M.D., PH.D., PROFESSOR OF MEDICINE n endstage lung disease, transplantation is sometimes the only viable therapeutic option, but organ availability is limited and rejection presents an additional challenge. Innovative research efforts in the field of tissue regeneration, including pioneerin

Working to FineTune the Immune System EYAL AMIEL, PH.D., ASSISTANT PROFESSOR OF MEDICAL LABORATORY AND RADIATION SCIENCES M icrobiologist Eyal Amiel, Ph.D., didnt think he wanted to study immunology, let alone make a career of it. But as coauthor of a paper recently published in the journal Nature Immunology, Amiel is at the forefront of research that could eventually lead to changes in vaccine design, along with new approaches to treating immunerelated diseases. Amiels research focuses on den

Solving a BloodType Mystery BRYAN BALLIF, PH.D., ASSOCIATE PROFESSOR OF BIOLOGY n the early 1950s, a 66yearold woman, sick with colon cancer, received a blood transfusion. Then, unexpectedly, she suffered a severe rejection of the transfused blood. Reporting on her case, the French medical journal Revue DHmatologie identified her as, simply, Patient Vel. After a previous transfusion, it turns out, Mrs. Vel had developed a potent antibody against some unknown molecule found on the red blood cells

Vermont Cancer Center Researchers Target Epigenetic Mechanisms to Advance Cancer Detection and Treatment esearchers at the Vermont Cancer Center VCC at the University of Vermont and Fletcher Allen Health Care are transforming the understanding of cancer biology and treatment of cancer. Investigations focus on molecular mechanisms of tumorcell malignancy, host factors and tumor growth, cancer control and population health science, as well as transdisciplinary team approaches to cancer research. A

A R E A O F F O C U S E D E X C E L L E N C E COMPLEX SYSTEMS The analysis of Big Data is an emerging strength at the University of Vermont, and a field in which the institution has already begun to blaze new pathways. Complex systems research draws upon sophisticated mathematical modeling techniques to analyze realworld challenges, from developing nextgeneration information technology for a national smart grid to mapping the global influence of social media. UVM has an outstanding cadre of

Associate Professor of Computer Science Joshua Bongard, Ph.D., has created robots that can actually change their body forms while learning how to walk. His research in evolutionary robotics is funded by the National Science Foundation. generations of the creatures then run a software routine, called a genetic algorithm, that experiments with various motions until it develops a slither, shuffle, or walking gait, based on its body plan, that can get it to the light source without tipping over. S

From Bacteria to Biofuels Understanding Cellular Survival MARY DUNLOP, PH.D., ASSISTANT PROFESSOR OF COMPUTER SCIENCE M ary Dunlop, Ph.D., is looking into how organisms respond to changing environments, and in doing so, shes crossing disciplines, using synthetic and systems biology to research natural and manufactured cellular processes. Dunlop, assistant professor in the School of Engineering and associate faculty member in the Vermont Complex Systems Center, was the recipient of the National

The Dow Jones of Happiness PETER DODDS, PH.D., PROFESSOR OF MATHEMATICS STATISTICS AND DIRECTOR OF THE COMPLEX SYSTEMS CENTER CHRISTOPHER DANFORTH, PH.D., ASSOCIATE PROFESSOR OF MATHEMATICS STATISTICS AND FLINT PROFESSOR OF MATHEMATICAL, NATURAL, AND TECHNICAL SCIENCES W ant to measure how financial markets are faring Check Dow Jones or the SP 500. Want to measure how happy the world was yesterday Check... wait a minute. You cant measure global happiness, can you Yes you can weve built a to

Leading the Charge for Smarter Electric Vehicle Management PAUL HINES, PH.D., ASSISTANT PROFESSOR OF COMPUTER SCIENCE JEFF FROLIK, PH.D., ASSOCIATE PROFESSOR OF ENGINEERING rowth in plugin electric car sales is good news for the environment in terms of oil consumption and air pollution. But this growing fleet will put new strain on the nations aging electrical distribution systems, like transformers and underground cables, especially at times of peak demand say, six in the evening when people c

4 Questions The Lake Champlain Watershed JUDITH VAN HOUTEN, PH.D., UNIVERSITY DISTINGUISHED PROFESSOR OF BIOLOGY AND DIRECTOR OF THE VERMONT GENETICS NETWORK s Vermonts climate becomes warmer, wetter and more volatile, the need for researchbased predictive tools to inform policy and landuse decisions in the state has never been greater. A 20 million grant from the National Science Foundation to Vermont EPSCoR is helping Vermont develop just this innovative decisionmaking capability, placing it a

A R E A O F F O C U S E D E X C E L L E N C E ENVIRONMENTAL SCIENCE One hundredfifty years ago, Vermonter George Perkins Marsh was the first writer to propose that human beings were agents of change, that the world as we know it is the result of the confluence of both natural phenomena and human activity. Today, in the hall that bears his name and in collaborations across campus, UVM faculty are conducting research to help us understand, engage and protect the world we live in. Ranging from

Tracking the Greenland Ice Sheets Big Melt PAUL BIERMAN, PH.D., PROFESSOR OF GEOLOGY f the whole Greenland ice sheet which covers more than 80 percent of the country were to melt, global sea level would rise twentythree feet, drowning coastal cities on every continent. Warm spells are becoming increasingly common in Greenland during the summer of 2012 the surface of the ice sheet melted over a far greater area than ever before observed. But the deeper details are devilishly important. Exactly

Calculating the Benefits of Nature TAYLOR RICKETTS, PH.D., GUND PROFESSOR OF ECOLOGICAL ECONOMICS AND DIRECTOR OF THE GUND INSTITUTE W hen Professor Taylor Ricketts talks about making advancements in global conservation efforts, he isnt so much worried about fuzzy little creatures necessarily, unless theyre native bees. Ricketts is interested in ecosystem services the economic benefits nature provides and in calculating their value in terms of finances, but also in their financial, cultural,

Examining the Health Effects of Biodiesel Fuel NAOMI FUKAGAWA, M.D., PH.D., PROFESSOR OF MEDICINE W orldwide, air pollution claimed seven million lives in 2012, according to a report released in March 2014 by the World Health Organization. As America seeks to become less dependent on imported oil, the pressure has increased to use alternative fuels such as biodiesel. Over the past decade, annual production of fuel derived from vegetable oils or animal fats has spiked from 25 million to over 1.

Synthetic Chemicals and Breast Cancer Risk THOMAS AHERN, PH.D., M.P.H., ASSISTANT PROFESSOR OF SURGERY V ermont Cancer Center scientist Thomas Ahern, Ph.D., M.P.H., is interested in the potential roles of hormonal signaling, dietary patterns, and energy balance in cancer development, as well as interventions that help prevent cancer. He recently received a 450,000 Susan G. Komen Environmental Challenge Grant to study breast cancer associated with exposure to synthetic chemicals called phthalat

3 Questions Climate Change ASIM ZIA, PH.D., ASSOCIATE PROFESSOR OF COMMUNITY DEVELOPMENT AND APPLIED ECONOMICS nternational efforts to deal with climate change have been many experts argue a spectacular failure. United Nations treaties, including the 1997 Kyoto Protocol that the United States chose not to ratify, form a very leaky bucket for catching greenhouse gases. A new book, PostKyoto Climate Governance Routledge, by Associate Professor Asim Zia, Ph.D., a fellow in the Gund Institute for

A R E A O F F O C U S E D E X C E L L E N C E FOOD SYSTEMS Food systems play an important role locally, nationally and globally, by impacting soil and water quality, human health and nutrition, global economics, packaging and transportation interests, and overall food and energy security. The foundation of this nascent field of study is strongly represented in the existing and emerging strengths at UVM, building on our service as a landgrant university with a deep connection to Vermonts work

Putting Vermont Farms to the Test JOHN BARLOW, D.V.M., PH.D., ASSISTANT PROFESSOR OF ANIMAL SCIENCE tacked 15 high, 1,500 culture plates line the bench of John Barlows lab at UVM. This is the collection of just one day at one Vermont farmstead cheesemakers farm. Barlows largescale, entirefarm sampling hopes to come up with some novel pathogendetection technology that may be particularly useful to smallscale, onfarm cheesemakers. His research on various forms of Staphylococcus will fill in the ga

Vermont Wheat Makes a Comeback HEATHER DARBY, PH.D., EXTENSION ASSOCIATE PROFESSOR n the nineteenth century, Vermont farmers grew some 40,000 acres of wheat each year. But as the soils, railroads, and climate of the Midwest triumphed in the intense competition of grain commodity markets, Vermont wheat production steadily declined and all but disappeared. Wheat fields have begun to sprout once again in Vermont in the past decade, thanks in large part to the research and outreach of UVM Extension

AREA OF FOCUSED EXCELLENCE FOOD SYSTEMS UVM.EDUDISCOVERY 33

Into the Coffee Lands V. ERNESTO MNDEZ, PH.D., ASSOCIATE PROFESSOR OF PLANT AND SOIL SCIENCE rofessor Ernesto Mndez, Ph.D., knows that being an agronomist alone isnt enough to understand and affect the complex issues of agricultural sustainability and farmer wellbeing. Thats why hes devoted his research and teaching career to transdisciplinary and action approaches that integrate systemic thinking with ontheground impacts. Mndez leads UVMs Agroecology and Rural Livelihoods Group, a community of

3 Questions Getting to the Roots of Childhood Obesity RACHEL JOHNSON, PH.D., M.P.H., R.D., ROBERT L. BICKFORD, JR. PROFESSOR OF NUTRITION achel Johnson, Ph.D., M.P.H., R.D., has made a career of researching the science behind childhood obesity with 101 peerreviewed papers in scientific journals, 12 book chapters, and funded grants and contracts totaling nearly 3.5 million. Thanks to her authoritative research credentials and knack for communicating clearly, Johnson has become a goto national pu

A R E A O F F O C U S E D E X C E L L E N C E NEUROSCIENCE AND BEHAVIOR Interdisciplinary neuroscience and behavioral research at UVM spans the spectrum from genes and molecules to complex behaviors, with an active translational path from bench to bedside to community and back again. The new Vermont Center on Behavior and Health, founded in 2013 with 35 million in federal grants, complements several strong programs already in place at the University, including the Neuroscience, Behavior and

Diane Jaworski, Ph.D., right, and Andrew Tsen, M.D., are part of a UVM team discovering potential new brain cancer treatments. A Food Additives Potential Role in Brain Cancer Therapy DIANE JAWORSKI, PH.D., PROFESSOR OF NEUROLOGICAL SCIENCES A few studies have investigated acetate as a potential therapeutic agent, but none had examined its potential benefits in treating gliomas brain tumors that originate in the glial cells of the brain until Professor Diane Jaworskis research uncovered its

THESE ARE NOT DISORDERED PEOPLE. THE BIG SECRET IS THAT WE ALL HAVE THE SAME SECRET WERE ALL SUFFERING FROM DIFFERENT LIFE EVENTS THAT WERE DEALT TO US. IT TAKES AWAY THE US AND THEM MENTALITY. Karen Fondacaro, Ph.D. Clinical Professor of Psychology Karen Fondacaro, Ph.D., founded Connecting Cultures to provide mental health services to Vermonts growing population of refugees. A threeyear federal grant funds her efforts to bring effective psychological services to torture survivors. Serving V

Within the groups so far the center has run three with Bhutanese survivors and two with SomaliBantu, with two more upcoming, everyone, even the initially reluctant, has voiced through an interpreter his or her story. Part of the reason people open up, Fondacaro believes, is that the process is gradual. The clinicians begin by creating a sense of safety and trust through sitting, talking, singing, culture sharing. They teach mindfulness exercises and get to know their clients values, often using

THE TAKEHOME MESSAGE IS THAT IMPULSIVITY CAN BE DECOMPOSED, BROKEN DOWN INTO DIFFERENT BRAIN REGIONS ... AND THE FUNCTIONING OF ONE REGION IS RELATED TO ADHD SYMPTOMS, WHILE THE FUNCTIONING OF OTHER REGIONS IS RELATED TO DRUG USE. Hugh Garavan, Ph.D. In a key finding, diminished activity in a network involving the orbitofrontal cortex is associated with experimentation with alcohol, cigarettes and illegal drugs in early adolescence. These networks are not working as well for some kids as for ot

Professor of Communication Sciences and Disorders Barry Guitar, Ph.D., overcame a severe stutter in his youth. Today, with a quartercentury of federally financed research behind him, he advocates for the Lidcombe method of speech therapy. taking a waitandsee approach. Our own research has confirmed these findings. Q What is it about the therapy that, to this day, inspires the disdain of your academic colleagues in the U.S. and Europe, 20 years after it was developed A I think it goes against t

U N I V E R S I T Y O F V E R M O N T ECONOMIC DEVELOPMENT IMPACT Research universities such as UVM are economic engines that provide the raw power of innovative discoveries that propel the renewal of existing fields of commerce, or open the way to entirely new commercial ventures that revolutionize the way we live and work. The University is a fullfledged member of the world around it, and it plays a vital role in the economy of its community in all the ways community can be defined locally

UVM alumnus Robert Andosca, Ph.D., holds one of the MEMS devices developed from research done at UVM by Andosca and Professor of Physics Junru Wu, Ph.D. At left, a variety of small sensing devices under development at MicroGen Systems, the company formed by Andosca and Wu. theoretical and experimental work on the energy harvester was published in the journal Sensors and Actuators and became the seventh most downloaded paper of 2012 on the leading website Science Direct. And in 2013, the energy

Erasing Boundaries for the Blind M ichael Rosen has produced research related to people with disabilities for the past four decades, the last ten in the College of Engineering and Mathematical Sciences. It wasnt until he cofounded Engineering to Assist and Support You E.A.S.Y, LLC with a colleague and a former student, however, that he felt like his research truly impacted lives. This company represents the first time that something I have been involved with as an academic engineer will end up

The Office of Technology Commercialization Bringing Innovations to the Marketplace he growing support of the UVM Office of Technology Commercialization OTC for promising innovations is bringing more and more discoveries to the commercial marketplace. Some products have been the basis for startup companies, while others are licensed to existing companies. Increasingly, the further development of innovation occurs in the laboratory of the inventor in collaboration with the company to whom it has b

3 Questions Economic Impact of Globalization STEPHANIE SEGUINO, PH.D., PROFESSOR OF ECONOMICS P rofessor Stephanie Seguino is a macroeconomist studying the impact of globalization on income distribution and wellbeing. Shes earned the ear of policymakers worldwide by showing that, while women and ultimately children bear the brunt, the entire economy suffers when some are marginalized. Seguino was a major contributor to a recently released report from the United Nations Development Programme

Clinical Trials Research Translating to Improved Care Clinical trials are the testing of new treatments in humans after extensive laboratory research has been completed. Clinical trials find better ways to treat a specific disease and are a critical step in the development of new medications to treat diseases. Hundreds of externallyfunded clinical trials of new medicines have been conducted at UVM and Fletcher Allen in the last decade, most targeting the nations six most debilitating chronic dis

UVM FACTS GENERAL 223 years since UVM was chartered in 1791 as the fifth college in New England DISCOVER MORE Explore the opportunities to engage our scientists, partner on innovations and support the research mission. Visit UVM.EDUDISCOVERY 9,970 undergraduate students 89 of fulltime faculty hold the highest degree in their discipline 45 masters and 21 doctoral programs 10 schools and colleges 109 bachelors degree programs 35,614 degrees awarded since 2000 1,357 graduate st

DISCOVERY. INNOVATION. IMPACT. The 2014 Research Report of the University of Vermont is a publication of the Office of the Provost and the Office of the Vice President for Research. David V. Rosowsky, Ph.D. Provost and Senior Vice President John N. Evans, Ph.D. Interim Vice President for Research EDITORS Carole Whitaker Assistant Dean for Medical Communications Edward Neuert Creative Director Medical Communications Jeff Wakefield Associate Director University Communications ART DIRECTOR Steve

DISCOVER MORE Explore the opportunities to engage our scientists, partner on innovations and support the research mission. Visit UVM.EDUDISCOVERY

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