Get Adobe Flash player

2010

, 2010. 112 . , 2010. 104 . , , . Kidney Cancer Association. . , , , , . , 2010 ., 2010 ..

. . . , , , . FDA . , , , . , , . III , . . . , , . , . . , , . , . . , www.kidneycancer.org , , . . Paula E. Bowen Kidney Cancer Association , , , , , , . 3

, , . . , Nancy Moldawer, RN, MSN , , City of Hope Comprehensive Cancer Center Laura Wood, RN, MSN, OCN Cleveland Clinic Foundation Marisa Lozano, RN, OCN , M.D. Anderson Cancer Center Beth Manchen, MS, RN, OCN , , University of Chicago Medical Center Nancy Moldawer, RN, CoChair , , , City of Hope Comprehensive Cancer Center Lynda Pyle, SRN, BSc in Oncology, FETC , , , Royal Marsden H

Kidney Cancer Association Paula E. Bowen . , Ronald M. Bukowski, MD . , Cleveland Clinic Taussig Cancer Center Sarah Wise Miller , Eric D. Perakslis . . , . Centocor Research and Development David Perry , KL Gates William J. Perry . , GGF, Inc. Lois Stulberg , David A. Swanson, MD . , M.D. Anderson Cancer Center Peter Telford , Christopher G. Wood, MD . , M.D. Anderson Cancer Center Thomas Hutson, DO, PharmD, FACP , , , Baylor University

1. 2. 3. 4. 5. 6. 7. , 8. 9. THE KIDNEY CANCER ASSOCIATION 8 16 29 44 62 68 75 85 93 100 102 Kidney Cancer Association 1234 Sherman Ave. Suite 203 Evanston, IL 60202, 18473321051 www.kidneycancer.org officekidneycancer.org

45 , , , , , , . , , , , , , , , . , , , 5 . III . 6 . . , . , 2 . . 5 . , , , , , . 2 . , , , , . 1. 7

1 . , . . . , , , . , , , . . , . . , . , . , . , , . 2007 , , 1,4 1. American Cancer Society , , , , 51 000 2. , , 100 000 200 000 , 8 1.

3. , , . 2005 , . Food and Drug Administration FDA , . 2007 . , , , . . . , , , , . . , , , , , , . , . , , . , . , . , . . , , . , , , , . . , , . , .., , . , . 1. 9

, , , . , , . , . . . , , . . . , . . . , , . , . , . , . Kidney Cancer Association Kidney Cancer Association , , . Kidney Cancer Association 1847 3321051 www.kidneycancer.org. , , . . . , 10 1.

Kidney Cancer Association, , . . , , , , , . . , , . , , , . , . , Health on the NET. , , . www.rakpochki.net, , . Kidney Cancer Association. , , , . , , , , . . , . , , . . 1. 11

, , , . , , . , . . . , , . . , , . , , , , , , . , , von HippelLindau, VHL, 4. , , 5. , , , , . , , , , , 6. BirtHoggDube BHD , , , , . 12 1.

, . , , . . . . , , , . . . . , , . , , , . , . , , , , . , . , , , , . . . . , , . , . . , . 225 10 12 5 7,5 . , , . . , , , 1. 13

. , , . , , . , . , . . . 14 1.

71 , , . . , , , , . 28 , . , . , . , , . , , , . , . . , , , , , . , 2. 15

2 , , ... , , . American Cancer Society ACS, 8. 4 . 9. ACS 2008 54 000 10. , , . 2008 13 000 11. , , 100 000 200 000 , 12. , , . . . , . , , , , , . , . , , . , . , , , , , . . , . 20 25 . , , , . , . 1

, , . . 40 60 . 40 , , . , , , , , . , , , . , , , . . . , , . . , . , . , , . 2. 17

. , 66 75 . VHL. , 70 . VHL. , , , . , . . . , . , 15 . , , , I II 5 10 . . , . I, II. , . , . , 5 . , , . . , , . 18 2.

, BHD, . , . , . 5 . , , , . , , . . 1. , . , . , . 1 . , , . . , . , , . . 1 . , . . 2. 19

. , , . , , . , , , , , . , . . . , . , . . , . , , , . , . , . , . . . , . . 20 2.

, , , , . , . . . . , . , . . , , . . , , , , , . , . , . . . , , , , . , , . , . , . , . 2. 21

, , . . , . , , , , . . , . , . , , , , , . . , , , , . , . , . . . 15 . , , . , . , , , . , . . , 22 2.

. , , , . . . . . , , . . , . . , , . , . , . . , , , . . , . , . , , . . , . 2. 23

, , . , , . , , . , , . , . , . . , . . . 24 2.

, , . , American Joint Committee on Cancer, AJCC. TNM AJCC tumor T , node N metastasis M. T, N M . . .. . , 0 4, . , , T1a T1b. , . N . , , . N 0 2, , , . M , . M 0 1, , , . T, N M T TX T0 T1a 4 T1b 4 , 7 T2 7 T3a , , , T3b , 2. 25

, , T3c , T4 , , . N NX N0 N1 N2 M MX M0 M1 , , TNM T, N M, . , I IV . I T1aT1b, N0, M0. 7 , . . II T2, N0, M0. 7 . . III T1aT3b, N1, M0 T3aT3c, N0, M0. T N . , , . III , , , , . 26 2.

IV T4, N0N1, M0 T, N2, M0 T, N, M1. T, N M , , . IV , , , , , . I I Stage II Stage II III Stage III IV Stage IV b . , . , , . 1 4. , 1, . . . , 4, .. , , , . , , . , , , IV , . , . 2. 27

67 14 . . , , Johns Hopkins . . . , , , . , , , . . . , . , . , . . Cancer Patient Education Program , . . , . , , , , . , . 28 3.

3 . , , . , . , . , . , , , . , , 245 , , , , 13. . . , , , , . 1 1 . , , , , , . . , , . . , , . 3. 29

, . . , . , , , . . , . 14. , , . , , . , , , , . . . . , , . , , . , . . 30 3.

, . . , . , , , . , , 15. . . , 16. . , . . , , . , . . . . , , , , . , , . 3. 31

, , . . , , , , , , , . , . , , 17. . . , . . . , . . 32 3.

. , , , , , . , , . . , , , . . , . , , , . , , , . , , . , , , , . , . , , . , , . , . , 3. 33

. , , , . , , , . , , , . , , , , , . , . , . , , , . . , , , . . , . , . . , , , . . , , . , , . , . . , . , 34 3.

. , . . . , . , , . , . , . , , . . , . , , . . , , . , . , , . , , . , . . . , , , , . , , . , 3. 35

. , , , . . , , . , , . . , , , . , , . , . . . . . . , , , , . . , . , , . , , . , , , . , 36 3.

, , . , . , . . . , , . . . , , . . , , . , . . . , . , , . , . , . . , . . , , . , . , . . . . , 3. 37

. . . . , , . , . , , , . . . , . , . , . . , , . , . . . . , , . . , , , . , , , , . . , , . . , , . . , , . . , 38 3.

, , , 64 , 18. , , , , . . , , , , . , , . , , . , , . I II . TNM, . , . , 1 4, . 2 . 1 . , 1 . 4 . . , . , . 3. 39

. , . , . . , , . , , , , . , . , . , , . , , , , . , . , . . , , , , . . , . , I, II, III IV , . , , . , III, I. , , . I II . III 40 3.

, . IV , . , , . . . . , , , . . , . , . . , , . , , , , , , , , , . . , . . , , , , . , , . . , . 3. 41

. , . . . . . . . , . , . 42 3.

57 2004 . , , . . , . . , . . , 6 . . . , , . , , , . , , . 2005 , , . . . . , . . . . , , , . , , , . , . , , . . 2008 , . , , . , , . , . , . , , . , , . 4.

4 . . . , , , , , , . .. . . target ., .. . , , . , . , . , , . , , . , , . 44 , , . 4.

, , . , , . VEGF PDGF. , , , . . 2005 2006 FDA U.S. Food and Drug Administration, . . 2009 . FDA , . , , . , . , , . . , , . , , . , . , , , . , , . . . 4. 45

, . 5 . , , , . , . . , , . VEGF PDGF, , , Raf, . , . III, FDA , , , , 19. 200 . 400 2 200 , 12 . , . , . , , , . , , . , , , , , , . . , . 46 4.

. . , , . . , , VEGF PDGF. FDA 2006 . , . , , 20. 2007 , . , , . 50 , 25 12,5 . . 50 , 28 , 14 . 6 , .. 28 14 . . , . , , , . , , . , , , , , , , , , 4. 47

. , , . . . , , . , , , . 2009 . . , , . , , . , 800 , 1 2 . , , , . 200 . , . , 20 , , , , . , , , , , , , , , , , , . , , . FDA . GlaxoSmithKline www.gsk.com 48 4.

mTOR mTOR , . mTOR 2123. mTOR 2426. , mTOR, , . mTOR, , FDA . . mTOR , , . 3 626 3 . . FDA . , 1 . , , , , , , , , , , , . , . , , . , , . 30 . , , . mTOR. , . , , , 2 4. 49

. , , . , , , , . , , , , , , , , , , 27. , , , , , . , . , , . . . 10 , 1 , . , . 5 . , , . , , . . . , , , . FDA , , , 50 4.

. . VEGF, . VEGF . , . , , , . , , , , , , , , , , , , , , , , . . . , . , , , . . , , , 28. BRM. , . BRM , . BRM , , . BRM . BRM, 2 2 . , . 4. 51

2 2 . NK. , . NK , . 2 FDA 1992 . . , 2, Novartis. , . 2 , . , , 2 . 2, 15 8 , 14, . , , . , , 2, , . , . , . 2 10 , . 2 . , , , , , , , , , , , . , . 2 . 52 4.

, , . . , . , , . . , Schering Corporation, 2b. , Roche Laboratories, 2a. , . 13 29. , , , , , . . , 3 4 30. . , , , , . , . , , . , , , , , . , . , . , 5 20 , 31. . 4. 53

, , , , , , . . . , . , , . , . . , , . . . 4 14 , 30 . , , , , . , . , . 54 4. , .

, . , , . , , . , . , . , , . , . , . , . 612 . , . , , . , . , . . , . , . , , , . . . 4. 55

. , . . . , , . , . , . , , . , . , . . , . , , 32. . , , , . , 5 , 5 33. , , 35. , . , , . 56 4.

, , , , . , , , . . , . . , , , , , . , , . , , , . , . . . , , , . , . . , , . , . , . , . , 4. 57

. . , , . , . , . , , , . . , . 36. . , 2, 37. . . . . , . , . , . . . , 58 4.

, , , . 30 50 . 20 25 . , , , , , . . , , , . , , , . , , , . , . , .. , . , , . . . 4. 59

54 2004 , . , , . , . , , , . , 19 . , . , , . . 60, . , . , . . , , . . , . , . , . , , . , , . , , . . 60 4.

, 64 2002 , . , . . , . . , , , . , . . , , . , , . , . , 18 . III , FDA. , . , , , , , , , , . , , . , , , . , , . , , . 18 , . . , . , . . , ,

5 , , , . , , , . . , , . , . . , , . , , . . . . , , 62 5. , , .

. . FDA . , . , , , . National Cancer Institute , 38. , . , . . . , , . . , , , . , . . , . 5. 63

, , , . . , . , . . I I , . . , I, . I , , , . II II . , . II , , . III III . 1000 . , . III . 64 5.

, III . . . , , . . II III , , . , , . , . , , , , . , , , . , . , , . , , . , , . , , , . , . . Kidney Cancer Association www.kidneycancer.org , , . , , , , . , 5. 65

, , . NIH 974250. . , , , MEDLINE, , , . , , , , . , , , . , , . Kidney Cancer Association , . Kidney Cancer Association 18473321051. , , , . , . , . , . 66 5.

55 , , , , . , , , . , . 50 , . 18 . IV . , , , , , , . , . 2, . , . 2, , . , . , , . . . , , . 6. 67

6 , , . , , . , , . , . , . . , , . , . . , , . . . . , . . . , , . , . 68 6.

Kidney Cancer Association KCA , , . , KCA Kidney Cancer News. , Kidney Cancer Journal, . KCA, www.kidneycancer.org. . U.S. Centers for Disease Control Prevention www.cdc.gov . , , , , , . , . , , . . . , , . . , . . , , , . . 6. 69

. , , , . . , . , . , , , , . . , . , . . , . . . , . , , , . . , . , , , 12 . . . , . 70 6.

, , . . . , . , , , , , , , , . , , , , .. , . , . , . . , . , , , . , . , . . , . . , . . , , . , , . , . . , . 6. 71

, . . , . , , . , , . . , . , , . . , . , . American Institute for Cancer Research. , . . , , . , . , . , . . . , . 72 6.

. , , , , , . . , Kidney Cancer Association . . . . . , . . . , . . . , , . Cancer Information Service , , . , . , . , . , , , . , . 6. 73

34 2005 , , . . . , . . , , , . , , . . . . . , , , . , . , , , , . , , . , , . , . , , . , . , , . , . , . , , , . 74 7. ,

7 , . , , , , . , , , . , , , , . , , , . , , . Supportive Care, , . , , , , , , . , , , , , . , , , . . , , . 7. , 75

, . , , , , . , , , . . , . , , . . , , , , , , , . , , , , , . , . , . . , . . , . , , . , , 0 10 0 , 10 , . , , , , ... , . , , . , , . , . , , . . 76 7. ,

, , , . . , , , . . , , , . , , , , . . , , . , . , , , , . . , . . . , , , . . , , . . . , . . . , , 35 39. , , 7. , 77

, 40. , . , , , . , . , , , , , . , . . . , . , . , . , . , , , , , . , . . , , . , . , , . , . , , . , , American Institute for Cancer Research www.aicr.org. . 78 7. ,

, . , . . . , , , . , , , , . . , , , , . , , , FDA. , , , , , FDA . , , FDA. , , . , , . , . , , FDA. , , , . , . , , . , , . , , . 7. , 79

. , , . , , , . Essiac, . Essiac , . . 50 XX , , , . , , , , , . . , . , , . . , , , . , . . , , , . , , , , . . 80 7. ,

, . . , . , . , , . . . , . , , , . , , . . . , . . , , . , , . . , , . . , . , . , , , . , , . , , . 7. , 81

. . , , , , . , , . . , , , . . , , . . . , , . , , . , . . . , . Kidney Cancer Association www.kidneycancer.org. , , . . , , . . , . , 82 7. ,

. , , , , . , , , . , . . . , . , , . . 7. , 83

65 2000 . , . , . , , , , 2003 . . , . , . , , , . , , , , . , , , , . Kidney Cancer Association , , , , . 30 , . , . , . . , , . . , . . , . , . Kidney Cancer Association, . . , , , .

8 . . , , , , , . , , . , . . , . , . . . . . , . , . , . , 8. 85

, . , , . , , . . , . , , , . , . , . . , , . . , . , , , , .. , , . . , , . , . . . , 86 8.

. , . , . . David F. Cella, PhD, , , , , , 41. , , . . , . , . , , . , . . . . , . , . , , . , . . , . . . . , . . 8. 87

, , . , . , , , , , , , . . 42. , , . , , , , , , . , . , , , . , , , . , , . , , , . , . . Kidney Cancer Association , . . 88 8.

Kidney Cancer Association , . , . Kidney Cancer Association, www.kidneycancer.org. , , . Kidney Cancer Association , . . 18473321051. , . , . , , . , . , . , . , , , . . , . . . . , , , , , . . , , . , . , , , .

, , . , , , , . , . . . . , , , , , . , , . , , , . . , . . , , , . , , . , , , . , . , . . , . , . . , . . . , , . , Kidney Cancer Association Reflections A Guide to End of Life Issues

. Roger C. Bone, MD, . www.kidneycancer.org. . , . , , , . , , , . , . . 8. 91

63 . . , . . . , , , , . , , . . , 2. , . . , 2. 2 . , , , , , . , , . , . , . , . 2 , , . , , . . , . . , , , , . . 92 9.

9 , , . . , . , , . , www.Newfrontierincancer.org , Kidney Cancer Association , , , , , 18473321051. www.kidneycancer.org officekidneycancer.org , , , . Kidney Cancer Association. 79165860251. www.rakpochki.net mir rakpochki.net National Cancer Institute httpcis.nci.nih.gov , httpweb.ncifcrf.govresearchkidney httpcancertrials.nci.nih.gov

, National Coalition for Cancer Survivorship The Cancer Patients Guide to Talking with Your Doctor Cancer Survival Toolbox. httpwww.canceradvocacy.org Cancer Information Service National Cancer Institute Physician Data Query PDQ, . PDQ , . PDQ , . Cancer Information Service . , , Comprehensive Cancer Centers. . National Cancer Institute www.clinicaltri

, , National Coalition for Cancer Survivorship Cancer Survival Toolbox, , www.canceradvocacy.org Center for MindBody Medicine www.cmbm.org, Research Resources National Center for Complementary and Alternative Medicine httpnccam.nih.gov Quack Watch www.quackwatch.com , www.newfrontierincancer.org www.avastin.com A www.introna.com www.nexavar.com 2 www.proleukin.com www.rocheusa.comproductsroferon www.sutent.com www.wye

Cancercare www.cancercare.org Cancer Net ASCO www.cancer.netCancercancer.html 4 4th Angel www.clevelandclinic.orgcancerscottcares4thangelabout.asp Wellness Community www.thewellnesscommunity.org Gildas Club www.gildasclub.org Coping www.copingmag.com American Association for Cancer Research www.aacr.org ChemoCare.com www.chemocare.com Lance Armstrong Foundation www.laf.org National Cancer Institute www.cancer.gov Medlineplus www.medlinepl

www.caring4cancer.com www.Cancer.gov CancerMeds HumorHope httpwww.cancer.med.umich.edushare1share.htm Kidney Cancer Association , . , , , . , , www.kidneycancer.org. Medline. National Library of Medicine , MEDLINE. MEDLINE , , , . , httpwww.ncbi.nlm.nih.gov PubMed. , , MEDLINE , , . . National Library of Medicine MEDLARS

American Institute for Cancer Research AICR www.aicr.org American Cancer Society www.cancer.org , www.cancer.govcancerinfoeatinghints www.boost.com Ensure Supplement www.ensure.com Kidney Cancer Association www.kidneycancer.org. . Reflections A Guide to End of Life Issues for You and Your Family. . . Wilms Tumor A Practical Guide for the Parents of Children with Wilms Tumor. The Kidney Cancer Journal www.kidneycancerjo

What You Need to Know About Kidney Cancer P023 Why Do You Smoke P145 . Advanced Cancer Living Each Day P084 . Chemotherapy and You A Guide to SelfHelp During Treatment P117 , Eating Hints For Cancer Patients Before, During and After Treatment P118 . Radiation Therapy and You A Guide to SelfHelp During Cancer Treatment P123 Talking With Your Child About Cancer P130 . When Cancer Recurs Meeting the Challenge Again P129 When So

The Kidney Cancer Association 1989 , , . Kidney Cancer Association, 1990 . . , . . www.kidneycancer.org. , . 23 . , . , , , . , , . , , , , , Kidney Cancer Association, Kidney Cancer Association 1234 Sherman Ave. Suite 203, Evanston, IL 60202, USA, , 18473321051 officekidneycancer.org , . , www.kidneycancer.org

. . , , . THE KIDNEY CANCER ASSOCIATION 101

1. 1. American Cancer Society, Estimated New Cancer Cases and Deaths by Sex for All Sites, 2008 available at www.cancer.org 2. American Cancer Society, Estimated New Cancer Cases and Deaths by Sex for All Sites, 2008 available at www.cancer.org 3. National Cancer Institute, Surveillance, Epidemiology and End Results SEER, Cancer of the Kidney and Renal Pelvis available at httpseer.cancer.govstatfacts 4. Neumann HP, Bender BU, Berger DP, et al. Prevalence, morphology and biology of renal cel

17. Rodriguez R, Chan DY, Bishoff JT, et al. Renal ablative cryosurgery in selected patients with peripheral renal masses. Urology. 2000552530. 18. Wolf JS JR, Seifman BD, Montie JE. Nephron sparing surgery for suspected malignancy open surgery compared to laparoscopy with selective use of hand assistance. J Urol. 2000163 16591664. 4. 19. Escudier B, Szczylik C, Eisen T, et al Randomized phase III trial of the Raf kinase and VEGFR inhibitor sorefenib BAY 439006 in patients with advanced r

36. Moscovitch M, Slavin S. Antitumor effects of allogeneic bone marrow transplantation in NZB X NZWF1 hybrids with spontaneous lymphosarcoma. J Immunol. 19841329971000. 37. Childs RW, Clave E, Tisdale J, Plante M, Hensel N, Barrett J. Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheralblood progenitorcell transplant evidence for a graftversustumor effect. J Clin Oncol. 1999172044. 5. 38. National Institutes of Health. Taking Part in Clinical

KIDNEY CANCER ASSOCIATION 08.11.2011 609016 500 . 50. . 109147, , , 2

Convert PDF to Flash Digital FlipBooks